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Index > Protein center > A2M(Gene name) > Bovine
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  • A2M (Gene name),
  • Alpha-2-macroglobulin (Protein name ),  A2MG_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    A2M;
    Protein name:
    Alpha-2-macroglobulin(Alpha-2-M);
    Alternative:

    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Homotetramer; disulfide-linked.
    Function:
    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1510
    Sequence:
    50:
    MGKNKLLYPS | LTLLLLLLLP | TDASVSGKPQ | YMVLVPSLLH | TETPEKGCLL | 
    100:
    LSHLNETVTV | SASLESVREN | RSLFTDVVAE | KDLFHCVSFT | LPRSPTSQEV | 
    150:
    MFLTIQVKGP | TQEFKKRTTV | LVKNEESLVF | VQTDKPIYKP | EQTVKFRIVL | 
    200:
    LDESFHPLNE | LVPLVYVEDP | KGNRIAQWQN | LEVENGLQQL | TFPLSSEPFQ | 
    250:
    GSYKVVVQKG | SGGTAEHPFT | VEEFVLPKFE | VQVRMPKIIT | ILEEEVQVSV | 
    300:
    CGLYTYGKPV | PGRVTMNMCR | KYRNPSNCYG | EESNAVCEKF | SGELNNEGCF | 
    350:
    SQQVNTKIFQ | LKRQEFEMKI | EVEAKIQEEG | TEVELTGKGA | TEITTTITKL | 
    400:
    SFVTVDSNLR | RGIPFTGKVL | LVDGKGVPMP | NKVIFITANE | ANHNSNTTTD | 
    450:
    EHGLAQFSIT | TTKIKGTSLS | IRVKYKDHSP | CYGYQWLSEE | HQDAYHSANL | 
    500:
    VFSRSNSFVY | LEPLPRELPC | GKTQTVQAHY | VLKGQVLKDL | KELVFYYLIM | 
    550:
    AKGGIVRSGT | HTLPVEQGDM | QGHFSMSVPV | ESDIAPVARL | LIYAILPDGE | 
    600:
    VVGDSARYEI | EHCLANKVGL | NFSPGQSFPA | SQAHLRVTAS | PQSLCALRAV | 
    650:
    DQSVLLMRPE | AELSAATVYN | LLPVKDLSSF | PSSVNQQEED | NEDCISHDNV | 
    700:
    YINGIMYFPV | SNTNEKDMYS | FLQDMGLKAF | TNSKIHKPKI | CPQPEEHRIQ | 
    750:
    HHTLLASPVR | AEMGRNRDFV | HFDDTSEPPT | ETVRKYFPET | WIWDLVVVSS | 
    800:
    SGVHEVEVTV | PDTITEWKAG | ALCLSRDTGL | GLSPTASLRV | FQPFFVELTM | 
    850:
    PYSVIRGEAF | TLKATVLNYL | PKCIRVSVQL | EASPAFLAVP | EKEQETYCIC | 
    900:
    GNGRQTVSWA | VTPKSLGNVN | FTVSAEAVES | QELCGSEVPV | VPEHGRKDTI | 
    950:
    IKPLLVEPEG | LEKEVIFNSL | LCPSVDFVFL | GAEDGGQVLR | HFPPAAATDT | 
    1000:
    AADAHDPARP | GAKVSESLSL | KLPPNVVEES | ARASFSVLGD | ILGSAMRNTQ | 
    1050:
    NLLQMPYGCG | EQNMARFAPN | IYVLDYLNET | QQLTAELKSK | AILYLNTGYQ | 
    1100:
    RQLLYKHFDG | SYSTFGEHRG | NSEGNTWLTA | FVLKSFAQAR | GYIFIDEAHI | 
    1150:
    TEALTWLAQK | QKSNGCFRST | GTLLNNAIKG | GVDDEVTLSA | YITIALLEMP | 
    1200:
    LPVTHPVVRN | ALFCLDSAWK | SAKEGSQGSH | VYTKALLAYA | FALAGNQERR | 
    1250:
    TEVLTSLYEE | AVKEDNTIHW | TRPQKPRLLT | EDIYQPRAPS | AEVEMTAYVI | 
    1300:
    LAHVTAQPAP | NPEDLKRATS | IVKWISKQQN | CQGGFSSTQD | TVVALHALSR | 
    1350:
    YGAATFTSAR | KAAQVTIQSS | GTFSTKFQVE | NSNRLLLQQV | SLPEVPGEYS | 
    1400:
    MSVTGEGCVY | LQTSLKYNIL | PKKDEFPFAL | EVQTLPQTCD | GPKAHTSFQI | 
    1450:
    SLSVSYIGSR | PASNMAIVDV | KMVSGFIPLK | PTVKMLERSN | VSRTEVSNNH | 
    1500:
    VLIYLDKVTN | ETLTLTFTVL | QDIPVRDLKP | AIVKVYDYYE | TDEFAVAEYS | 
    1510:
    APCSKDIGNA | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Alpha-2-M
    Cat.:
    E1017r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Alpha-2-M
    Cat.:
    E1017b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Alpha-2-M
    Cat.:
    E1017m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine Alpha-2-M
    Cat.:
    E1017h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine Alpha-2-M
    Cat.:
    U1017h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine Alpha-2-M
    Cat.:
    U1017m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Alpha-2-M
    Cat.:
    U1017b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine Alpha-2-M
    Cat.:
    U1017r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine Alpha-2-M
    Polyclonal Antibody for Bovine Alpha-2-M
    Cat.:
    P1017Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Alpha-2-M
    Cat.:
    P1017Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine Alpha-2-M
    Cat.:
    P1017Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine Alpha-2-M
    Monoclonal Antibody for Bovine Alpha-2-M
    Monoclonal Antibody for Bovine Alpha-2-M
    Monoclonal Antibody for Bovine Alpha-2-M
    Protein for Bovine Alpha-2-M
    Protein for Bovine Alpha-2-M
    Protein for Bovine Alpha-2-M
    Protein for Bovine Alpha-2-M

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    References
    1. 1.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2007-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Hereford.
      tissue: Fetal liver.
    2. 2.
      "Crystal structure of the receptor-binding domain of alpha 2-macroglobulin."
      Jenner L. , Husted L. , Thirup S. , Sottrup-Jensen L. , Nyborg J.
      Structure6:595-604(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1375-1504;PARTIAL PROTEIN SEQUENCE;DISULFIDE BOND;GLYCOSYLATION AT ASN-1440
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